Open AccessDirect micropuncture evidence that matrix extracellular phosphoglycoprotein inhibits proximal tubular phosphate reabsorption
Author(s) -
David G. Shirley,
Nuno Faria,
Robert J. Unwin,
Hamish Dobbie
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq263
Subject(s) - reabsorption , nephron , convoluted tubule , phosphate , tubular fluid , medicine , endocrinology , kidney , extracellular fluid , proximal tubule , renal physiology , excretion , renal function , loop of henle , chemistry , extracellular , biochemistry
Matrix extracellular phosphoglycoprotein (MEPE) is a putative phosphatonin that we have shown in previous studies to be phosphaturic in rats. Its site of action in the nephron remains to be confirmed.
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