Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF- 1-stimulated NRK-49F cells | Zendy

Bin Zhu | Zendy; Y.-j. Wang | Zendy; C.-f. Zhu | Zendy; Yufan Lin | Zendy; Xue-Xin Zhu | Zendy; Wei Shen | Zendy; Yuqiu Lu | Zendy; Xinqi Cheng | Zendy

Open Access

Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF- 1-stimulated NRK-49F cells

Author(s) -

Bin Zhu,

Y.-j. Wang,

C.-f. Zhu,

Yufan Lin,

Xue-Xin Zhu,

Wei Shen,

Yuqiu Lu,

Xinqi Cheng

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq239

Subject(s) - triptolide , fibronectin , extracellular matrix , mapk/erk pathway , transfection , microbiology and biotechnology , type i collagen , medicine , signal transduction , chemistry , cell culture , biology , biochemistry , apoptosis , genetics

Triptolide has been used for treating various autoimmune diseases. However, it remains unclear whether triptolide exerts effects on extracellular matrix (ECM) synthesis, which plays an important role in renal fibrosis.

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