Open AccessRapamycin-induced phosphaturia
Author(s) -
Daniela S. Kempe,
Miribane DërmakuSopjani,
Holger Fröhlich,
Mentor Sopjani,
AnneKathrin Umbach,
Goverdhan Puchchakayala,
Anna Capasso,
F. Weiss,
Michael Stübs,
Michael Föller,
Florian Läng
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq172
Subject(s) - xenopus , pi3k/akt/mtor pathway , phosphate , endocrinology , medicine , transporter , cotransporter , in vivo , biology , chemistry , microbiology and biotechnology , signal transduction , biochemistry , organic chemistry , gene , sodium
The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa.
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