Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats | Zendy

Xiao-Hui Liao | Zendy; Lei Zhang | Zendy; Q. Liu | Zendy; Hang Sun | Zendy; Chao Peng | Zendy; Hui Guo | Zendy

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Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats

Author(s) -

Xiao-Hui Liao,

Lei Zhang,

Q. Liu,

Hang Sun,

Chao Peng,

Hui Guo

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq151

Subject(s) - medicine , proliferating cell nuclear antigen , kidney , immunohistochemistry , acute kidney injury , renal function , ischemia , intraperitoneal injection , pathology , reperfusion injury , liver regeneration , hepatocyte , endocrinology , regeneration (biology) , biology , in vitro , biochemistry , microbiology and biotechnology

Augmenter of liver regeneration (ALR), which was identified originally for its crucial role in promoting hepatocyte proliferation, is expressed in both the liver and kidney. Protective effects of ALR have been demonstrated in experimental models of acute liver failure. In the present study, we investigated the effect of ALR on renal ischaemia/reperfusion (I/R) injury and the possible mechanisms of its action.

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