Dinucleoside polyphosphates: newly detected uraemic compounds with an impact on leucocyte oxidative burst | Zendy

Eva Schepers | Zendy; Griet Glorieux | Zendy; V. Jankowski | Zendy; Annemieke Dhondt | Zendy; Joachim Jankowski | Zendy; Raymond Vanholder | Zendy

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Dinucleoside polyphosphates: newly detected uraemic compounds with an impact on leucocyte oxidative burst

Author(s) -

Eva Schepers,

Griet Glorieux,

V. Jankowski,

Annemieke Dhondt,

Joachim Jankowski,

Raymond Vanholder

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq080

Subject(s) - respiratory burst , monocyte , biochemistry , guanosine , phosphate , reactive oxygen species , nucleotide , oxidative phosphorylation , adenosine triphosphate , platelet , intracellular , stimulation , lymphocyte , medicine , chemistry , gene

Dinucleoside polyphosphates (Np(n)N) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells. Although their impact on several cell systems involved in vascular damage (endothelium, smooth muscle cells and thrombocytes) has been evaluated, their effect on different types of leucocytes has never been studied.

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