Open AccessThe effect of progressive glomerular disease on megalin-mediated endocytosis in the kidney
Author(s) -
L. Vinge,
George E. Lees,
Rikke Nielsen,
Clifford E. Kashtan,
Anne Bahr,
Erik Christensen
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfq044
Subject(s) - endocytosis , proteinuria , medicine , glomerular basement membrane , reabsorption , endocrinology , renal function , kidney , receptor
A well-characterized dog model of the X-linked collagen disease Alport syndrome (XLAS) was used to study the effect of progressive glomerular disease on megalin-mediated endocytosis. In XLAS, altered structure and function of the glomerular basement membrane induces a progressive proteinuric nephropathy.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom