The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients | Zendy

Sophie Liabeuf | Zendy; Daniela Veit Barreto | Zendy; Fellype Carvalho Barreto | Zendy; Maud Chasseraud | Zendy; Michel Brazier | Zendy; Gabriel Choukroun | Zendy; Saı̈d Kamel | Zendy; Ziad A. Massy | Zendy

Open Access

The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients

Author(s) -

Sophie Liabeuf,

Daniela Veit Barreto,

Fellype Carvalho Barreto,

Maud Chasseraud,

Michel Brazier,

Gabriel Choukroun,

Saı̈d Kamel,

Ziad A. Massy

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq042

Subject(s) - medicine , kidney disease , renal function , dialysis , gastroenterology , cohort , inflammation , population , c reactive protein , hemodialysis , body mass index , serum albumin , immunology , environmental health

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and an inadequate inflammatory response which may account for the high morbidity and mortality observed in this population. In vitro and preclinical evidence suggests that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) might be involved in both the atherosclerosis pathway and modulation of the inflammatory response. The aim of the present study was thus to (i) determine serum levels of soluble TRAIL (sTRAIL) in a cohort of CKD patients, (ii) assess the relationship between sTRAIL and other inflammatory biomarkers (C-reactive protein and albumin) and (iii) evaluate the association between serum sTRAIL levels and the mortality risk.

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