A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13 | Zendy

Michael Knecht | Zendy; Michael Mayr | Zendy; Silvia Ferrari | Zendy; Friedrich Scheiflinger | Zendy; Marten Trendelenburg | Zendy

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A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13

Author(s) -

Michael Knecht,

Michael Mayr,

Silvia Ferrari,

Friedrich Scheiflinger,

Marten Trendelenburg

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfq021

Subject(s) - adamts13 , thrombotic microangiopathy , medicine , antibody , thrombotic thrombocytopenic purpura , immunology , neutralizing antibody , microangiopathy , platelet , disease , endocrinology , diabetes mellitus

In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.

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