Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis | Zendy

Estela Nogueira | Zendy; Sally Hamour | Zendy; Devika Sawant | Zendy; John Henderson | Zendy; Neil J. Mansfield | Zendy; KM Chavele | Zendy; C. D. Pusey | Zendy; Alan D. Salama | Zendy

Open Access

Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis

Author(s) -

Estela Nogueira,

Sally Hamour,

Devika Sawant,

John Henderson,

Neil J. Mansfield,

KM Chavele,

C. D. Pusey,

Alan D. Salama

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp783

Subject(s) - medicine , convalescence , elispot , immunology , interleukin 17 , vasculitis , interleukin 23 , pathogenesis , cytokine , anti neutrophil cytoplasmic antibody , t cell , disease , immune system

The Th17 subset has been implicated in the pathogenesis of a number of autoimmune diseases. However, little is known about its role in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). We measured serum levels of IL-17A and associated upstream cytokines and the frequency of IL-17-producing autoantigen-specific T cells in patients with AAV.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research