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Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10
Author(s) -
Sufyan G. Sayyed,
Anil Bhanudas Gaikwad,
Julia Lichtnekert,
Onkar P. Kulkarni,
Dirk Eulberg,
Sven Klußmann,
Kulbhushan Tikoo,
HansJoachim Anders
Publication year - 2010
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp730
Subject(s) - histone , medicine , epigenetics , acetylation , nephropathy , diabetic nephropathy , glomerulosclerosis , endocrinology , cancer research , diabetes mellitus , proteinuria , biochemistry , kidney , biology , gene
Distinct histone modifications regulate gene expression in certain diseases but little is known about histone epigenetics in diabetic nephropathy. The current study examined the role of histone epigenetics in development and progression of nephropathy in db/db mice.

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