Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy | Zendy

Michele Rossini | Zendy; Toshio Naito | Zendy; Haichun Yang | Zendy; Michael L. Freeman | Zendy; Ellen Donnert | Zendy; Jarogniew J. Łuszczki | Zendy; Stephen Dunn | Zendy; Konika Sharma | Zendy; Agnes B. Fogo | Zendy

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Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy

Author(s) -

Michele Rossini,

Toshio Naito,

Haichun Yang,

Michael L. Freeman,

Ellen Donnert,

Jarogniew J. Łuszczki,

Stephen Dunn,

Konika Sharma,

Agnes B. Fogo

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp724

Subject(s) - medicine , endocrinology , albuminuria , kidney disease , creatinine , diabetic nephropathy , nephropathy , renal function , proteinuria , kidney , diabetes mellitus , urology

Sulodexide is a glycosaminoglycan with anticoagulant and antithrombotic activities. Although sulodexide reduced albuminuria in patients with type 1 and type 2 diabetes, long-term effects on chronic renal injury are not established. We investigated sulodexide effects and mechanisms in a rat radiation nephropathy model and in the db/db mouse model of diabetic kidney disease.

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