Role of p21 and oxidative stress on renal tubular resistance after acute ischaemic injury | Zendy

Flavia Kfouri | Zendy; Isac de Castro | Zendy; Leonardo Testagrossa | Zendy; Humberto Dellê | Zendy; Ana Maria Gonçalves da Silva | Zendy; Ana Paula Bastos | Zendy; José Mauro Vieira | Zendy; Luís Yu | Zendy

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Role of p21 and oxidative stress on renal tubular resistance after acute ischaemic injury

Author(s) -

Flavia Kfouri,

Isac de Castro,

Leonardo Testagrossa,

Humberto Dellê,

Ana Maria Gonçalves da Silva,

Ana Paula Bastos,

José Mauro Vieira,

Luís Yu

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp719

Subject(s) - medicine , oxidative stress , creatinine , renal function , tunel assay , ischemia , endocrinology , necrosis , lactate dehydrogenase , kidney , pathology , urology , biochemistry , immunohistochemistry , chemistry , enzyme

Subsequent ischaemic episodes may induce renal resistance. P21 is a cell cycle inhibitor that may be induced by oxygen-free radicals and may have a protective effect in ischaemic acute kidney injury (AKI). This study aimed at evaluating the role of oxidative stress and p21 on tubular resistance in a model of acquired resistance after renal ischaemia and in isolated renal tubules.

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