Rapidly progressive glomerulonephritis complicating primary AL amyloidosis and multiple myeloma | Zendy

A. Crosthwaite | Zendy; Alison Skene | Zendy; Peter F. Mount | Zendy

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Rapidly progressive glomerulonephritis complicating primary AL amyloidosis and multiple myeloma

Author(s) -

A. Crosthwaite,

Alison Skene,

Peter F. Mount

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp715

Subject(s) - medicine , rapidly progressive glomerulonephritis , amyloidosis , multiple myeloma , glomerulonephritis , al amyloidosis , complication , pathology , renal biopsy , biopsy , kidney , immunology , antibody , immunoglobulin light chain

Crescentic glomerulonephritis is a rare complication of AA amyloidosis. There are no clinical case reports of this complicating AL amyloidosis. A 67-year-old man developed rapidly progressive glomerulonephritis (RPGN) on a background of primary AL amyloidosis and IgGkappa multiple myeloma. Investigations for causes of glomerulonephritis were negative, and a renal biopsy confirmed crescentic glomerulonephritis and amyloid deposition. He progressed to end stage kidney disease (ESKD) requiring dialysis after 2 months and died 7 months after diagnosis after further treatment of multiple myeloma failed to arrest progression. We believe this to be the first clinical case report of RPGN complicating primary (AL) renal amyloidosis and multiple myeloma.

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