Open AccessThe Rowett rat strain is resistant to renal fibrosis
Author(s) -
Gábor Kökény,
Zsuzsanémeth,
Mária Godó,
Péter Hamar
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp689
Subject(s) - medicine , nephrectomy , fibrosis , strain (injury) , urology , kidney , endocrinology , surgery , cardiology
Genetic susceptibility to renal fibrosis may determine the individual rate of progression to renal failure. We aimed to study the progression in Rowett (RO) rats, a strain we found resistant to subtotal nephrectomy (SNX), comparing to Sprague-Dawley (SD) rats, a strain with established sensitivity in a radical ablation/infarction and diet-induced SNX model.
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