Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients | Zendy

KookHwan Oh | Zendy; Ji Yong Jung | Zendy; Myeong Ok Yoon | Zendy; Ahui Song | Zendy; H. Lee | Zendy; Han Ro | Zendy; YoungHwan Hwang | Zendy; Dong Ki Kim | Zendy; Peter J. Margetts | Zendy; Curie Ahn | Zendy

Open Access

Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients

Author(s) -

KookHwan Oh,

Ji Yong Jung,

Myeong Ok Yoon,

Ahui Song,

H. Lee,

Han Ro,

YoungHwan Hwang,

Dong Ki Kim,

Peter J. Margetts,

Curie Ahn

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp670

Subject(s) - medicine , peritoneal equilibration test , peritoneal dialysis , endocrinology , peritonitis , peritoneal cavity , inflammation , creatinine , angiogenesis , renal function , gastroenterology , albumin , surgery , continuous ambulatory peritoneal dialysis

Interleukin-6 (IL-6) is a key player in modulating inflammation. IL-6 and soluble IL-6 receptor (sIL-6R) complex induces the synthesis and secretion of various chemokines, adhesion molecules and angiogenic molecules. We hypothesized that the baseline peritoneal solute transport rate (PSTR) early after commencing peritoneal dialysis (PD) may depend largely on the IL-6/sIL-6R system. We also hypothesized that the dialysate concentrations of IL-6/sIL-6R could be closely related to local inflammation or angiogenesis in the peritoneal cavity.

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