Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis? | Zendy

Philipp Kalk | Zendy; Matthias Rückert | Zendy; Michael Godes | Zendy; Karoline von Websky | Zendy; Katharina Relle | Zendy; H.-H. Neumayer | Zendy; Berthold Hocher | Zendy; Stanislao Morgera | Zendy

Open Access

Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis?

Author(s) -

Philipp Kalk,

Matthias Rückert,

Michael Godes,

Karoline von Websky,

Katharina Relle,

H.-H. Neumayer,

Berthold Hocher,

Stanislao Morgera

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp652

Subject(s) - medicine , peritoneal dialysis , endothelin receptor , fibrosis , peritoneum , receptor , urology , surgery

Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD); however, the mechanisms are poorly understood. The endothelin system exhibits potent pro-fibrotic properties and is known to be stimulated in peritoneal fibrosis. Thus, our study aimed at elucidating the impact of the endothelin B (ETB) receptor on peritoneal membrane thickening by means of an ETB-deficient rat model (ETB(-)(/)(-)) in experimental PD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research