BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure | Zendy

Jesús Loureiro | Zendy; Margot N. Schilte | Zendy; Abelardo Aguilera | Zendy; Patricia Albar-Vizcaíno | Zendy; Marta RamírezHuesca | Zendy; Marı́a Luisa Lozano | Zendy; Guadalupe Tirma González-Mateo | Zendy; Luiz Stark Aroeira | Zendy; Rafael Selgas | Zendy; Lorea Mendoza | Zendy; Alberto Ortíz | Zendy; Marta Ruiz–Ortega | Zendy; Jacob van den Born | Zendy; Robert H.J. Beelen | Zendy; Manuel LópezCabrera | Zendy

Open Access

BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure

Author(s) -

Jesús Loureiro,

Margot N. Schilte,

Abelardo Aguilera,

Patricia Albar-Vizcaíno,

Marta RamírezHuesca,

Marı́a Luisa Lozano,

Guadalupe Tirma González-Mateo,

Luiz Stark Aroeira,

Rafael Selgas,

Lorea Mendoza,

Alberto Ortíz,

Marta Ruiz–Ortega,

Jacob van den Born,

Robert H.J. Beelen,

Manuel LópezCabrera

Publication year - 2010

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp618

Subject(s) - medicine , peritoneum , fibrosis , pathology , mesothelium , angiogenesis , smad , vascular endothelial growth factor , masson's trichrome stain , mesothelial cell , transforming growth factor , cancer research , endocrinology , vegf receptors

During peritoneal dialysis (PD), mesothelial cells (MC) undergo an epithelial-to-mesenchymal transition (EMT), and this process is associated with peritoneal membrane (PM) damage. Bone morphogenic protein-7 (BMP-7) antagonizes transforming growth factor (TGF)-beta1, modulates EMT and protects against fibrosis. Herein, we analysed the modulating role of BMP-7 on EMT of MC in vitro and its protective effects in a rat PD model.

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