An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing | Zendy

Tetsu Miyamoto | Zendy; Masaru Tamura | Zendy; Narutoshi Kabashima | Zendy; Ryota Serino | Zendy; Tatsuya Shibata | Zendy; Y. Furuno | Zendy; M. Miyazaki | Zendy; Ryoko Baba | Zendy; N. Sato | Zendy; Yoshiaki Doi | Zendy; Masahiro Okazaki | Zendy; Yutaka Otsuji | Zendy

Open Access

An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing

Author(s) -

Tetsu Miyamoto,

Masaru Tamura,

Narutoshi Kabashima,

Ryota Serino,

Tatsuya Shibata,

Y. Furuno,

M. Miyazaki,

Ryoko Baba,

N. Sato,

Yoshiaki Doi,

Masahiro Okazaki,

Yutaka Otsuji

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp601

Subject(s) - peritoneal dialysis , medicine , mesothelial cell , wound healing , motility , fibronectin , peritoneal cavity , pathology , microbiology and biotechnology , cell , chemistry , biochemistry , surgery , biology

Bioincompatible peritoneal dialysis fluids (PDFs) cause pathological changes in the peritoneal membrane, related to membrane dysfunction and progressive peritoneal fibrosis. We investigated the effects of Pro-His-Ser-Arg-Asn (PHSRN) peptide, one of the fibronectin cell-binding domains that activates integrins and reinforces wound healing, on peritoneal remodelling in a rat peritoneal injury model undergoing peritoneal dialysis.

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