The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis | Zendy

Vincent Lee | Zendy; Xiaohong Qin | Zendy; Yiping Wang | Zendy; Guoping Zheng | Zendy; Jon Ince | Zendy; Tiong Kit Tan | Zendy; Lukas Kairaitis | Zendy; S. I. Alexander | Zendy; David C.H. Harris | Zendy

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The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis

Author(s) -

Vincent Lee,

Xiaohong Qin,

Yiping Wang,

Guoping Zheng,

Jon Ince,

Tiong Kit Tan,

Lukas Kairaitis,

S. I. Alexander,

David C.H. Harris

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp569

Subject(s) - medicine , innate immune system , nephrosis , stimulation , cd40 , cd154 , immunology , immune system , biochemistry , cytotoxic t cell , in vitro , chemistry

Blockade of CD40-CD40 ligand (CD154) interactions protects against renal injury in adriamycin nephropathy (AN) in immunocompetent mice. To investigate whether this protection relied on adaptive or cognate immunity, we tested the effect of CD40-CD154 blockade in severe combined immunodeficient (SCID) mice.

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