Open AccessProtection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of 2-adrenoceptor
Author(s) -
Akio Nakamura,
Ryo Niimi,
Y Yanagawa
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp561
Subject(s) - medicine , sepsis , gene delivery , endocrinology , kidney , renal function , pharmacology , genetic enhancement , biology , gene , biochemistry
Sepsis is a common cause of acute renal failure (ARF) and results in a high mortality rate. The objective of the present study was to evaluate adenoviral transgenes containing the human beta(2)-adrenoceptor (adeno-beta(2)-AR) as a possible therapy for subjects at high risk for developing sepsis-induced ARF.
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