Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS) | Zendy

Guillaume Canaud | Zendy; Dan Dion | Zendy; Julien Zuber | Zendy; MarieClaire Gubler | Zendy; Rebecca Sberro | Zendy; Éric Thervet | Zendy; Renaud Snanoudj | Zendy; Marina Charbit | Zendy; Rémi Salomon | Zendy; F. Martinez | Zendy; C. Legendre | Zendy; LaureHélène Noël | Zendy; Patrick Niaudet | Zendy

Open Access

Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS)

Author(s) -

Guillaume Canaud,

Dan Dion,

Julien Zuber,

MarieClaire Gubler,

Rebecca Sberro,

Éric Thervet,

Renaud Snanoudj,

Marina Charbit,

Rémi Salomon,

F. Martinez,

C. Legendre,

LaureHélène Noël,

Patrick Niaudet

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp500

Subject(s) - medicine , nephrotic syndrome , focal segmental glomerulosclerosis , proteinuria , transplantation , minimal change disease , incidence (geometry) , kidney transplantation , population , glomerulosclerosis , glomerulonephritis , retrospective cohort study , pathology , urology , gastroenterology , kidney , physics , environmental health , optics

Introduction. Recurrence of nephrotic-range proteinuria in patients with idiopathic nephrotic syndrome (INS) and focal and segmental glomerulosclerosis (FSGS) on native kidneys is associated with poor graft survival. Identification of risk factors for recurrence is therefore an important issue. In 2004, Columbia University introduced a histological classification of FSGS that identifies five mutually exclusive variants. In non-transplant patients, the Columbia classification appears to predict the outcome and response to treatment better than clinical characteristics alone. However, the predictive value of this classification to assess the risk of recurrence after transplantation has not been addressed.

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