Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction | Zendy

Dagan Jenkins | Zendy; Xavier Caubit | Zendy; Aleksandar Dimovski | Zendy; Nadica Matevska-Geshkovska | Zendy; Claire M. Lye | Zendy; Feryal Çabuk | Zendy; Zoran Gucev | Zendy; Velibor Tasić | Zendy; Laurent Fasano | Zendy; Adrian S. Woolf | Zendy

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Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction

Author(s) -

Dagan Jenkins,

Xavier Caubit,

Aleksandar Dimovski,

Nadica Matevska-Geshkovska,

Claire M. Lye,

Feryal Çabuk,

Zoran Gucev,

Velibor Tasić,

Laurent Fasano,

Adrian S. Woolf

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp453

Subject(s) - ureter , renal pelvis , gene , medicine , hydronephrosis , pelvis , urinary system , biology , anatomy , genetics , surgery

Congenital pelvi-ureteric junction obstruction (PUJO) affects 0.3% of human births. It may result from aberrant smooth muscle development in the renal pelvis, resulting in hydronephrosis. Mice that are null mutant for the Teashirt3 (Tshz3) gene exhibit congenital PUJO with defective smooth muscle differentiation and absent peristalsis in the proximal ureter.

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