Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70 | Zendy

Hidekazu Sugiura | Zendy; Tetsuya Yoshida | Zendy; Michihiro Mitobe | Zendy; Satoshi Yoshida | Zendy; S. Shiohira | Zendy; Kosaku Nitta | Zendy; K. Tsuchiya | Zendy

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Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70

Author(s) -

Hidekazu Sugiura,

Tetsuya Yoshida,

Michihiro Mitobe,

Satoshi Yoshida,

S. Shiohira,

Kosaku Nitta,

K. Tsuchiya

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp451

Subject(s) - klotho , medicine , kidney , tunel assay , apoptosis , acute kidney injury , hsp70 , real time polymerase chain reaction , creatinine , heat shock protein , andrology , endocrinology , immunohistochemistry , biology , gene , biochemistry

High Klotho expression has been detected in the kidney, and since the results of a recent study suggested that Klotho induction mitigates ischaemic damage in the kidney, in the present study we explored the mechanism by which Klotho expression reduces renal ischaemia-reperfusion injury (IRI).

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