Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina | Zendy

Andrzej Surdacki | Zendy; Ewa Marewicz | Zendy; Ewa WieczorekSurdacka | Zendy; Tomasz Rakowski | Zendy; Grzegorz Szastak | Zendy; J Pryjma | Zendy; Dariusz Dudek | Zendy; Jacek S. Dubiel | Zendy

Open Access

Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina

Author(s) -

Andrzej Surdacki,

Ewa Marewicz,

Ewa WieczorekSurdacka,

Tomasz Rakowski,

Grzegorz Szastak,

J Pryjma,

Dariusz Dudek,

Jacek S. Dubiel

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp439

Subject(s) - medicine , renal function , progenitor cell , endothelial progenitor cell , cardiology , coronary artery disease , nitric oxide , endothelial dysfunction , kidney disease , endocrinology , urology , stem cell , genetics , biology

Renal insufficiency predisposes to coronary artery disease (CAD), but also CAD and traditional risk factors accelerate renal function loss. Endothelial progenitor cell (EPC) deficiency and elevated asymmetrical dimethyl-L-arginine (ADMA), an endogenous nitric oxide (NO) formation inhibitor, predict adverse CAD outcome. Our aim was to assess changes in estimated glomerular filtration rate over time (DeltaeGFR) in relation to baseline EPC blood counts and ADMA levels in stable angina.

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