FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis | Zendy

Julien Zuber | Zendy; Albane Brodin-Sartorius | Zendy; Nathanaël Lapidus | Zendy; N. Patey | Zendy; Marie Tosolini | Zendy; Sophie Candon | Zendy; Marion Rabant | Zendy; Renaud Snanoudj | Zendy; Clarisse Panterne | Zendy; Éric Thervet | Zendy; C Legendre | Zendy; Lucienne Chatenoud | Zendy

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FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis

Author(s) -

Julien Zuber,

Albane Brodin-Sartorius,

Nathanaël Lapidus,

N. Patey,

Marie Tosolini,

Sophie Candon,

Marion Rabant,

Renaud Snanoudj,

Clarisse Panterne,

Éric Thervet,

C Legendre,

Lucienne Chatenoud

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp435

Subject(s) - medicine , foxp3 , fibrosis , inflammation , transplantation , pathology , regulatory t cell , cd3 , biopsy , creatinine , immunology , gastroenterology , t cell , immune system , cd8 , il 2 receptor

FOXP3-expressing regulatory T cells (Tregs) play a crucial role in maintaining allogeneic transplant tolerance in experimental models. In clinical transplantation, there are few data about their role in chronic inflammation. We hypothesized that Tregs might accumulate within the graft since enrichment of Tregs has been frequently described in chronically inflamed tissues.

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