Crystalluric and tubular epithelial parameters during the onset of intratubular nephrocalcinosis: illustration of the 'fixed particle' theory in vivo | Zendy

Benjamin A. Vervaet | Zendy; Patrick C. D’Haese | Zendy; Marc E. De Broe | Zendy; Anja Verhulst | Zendy

Open Access

Crystalluric and tubular epithelial parameters during the onset of intratubular nephrocalcinosis: illustration of the 'fixed particle' theory in vivo

Author(s) -

Benjamin A. Vervaet,

Patrick C. D’Haese,

Marc E. De Broe,

Anja Verhulst

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp418

Subject(s) - in vivo , osteopontin , nephrocalcinosis , clusterin , medicine , epithelium , microbiology and biotechnology , apoptosis , kidney , endocrinology , pathology , biophysics , biology , biochemistry

The 'fixed particle' theory states that, besides crystal formation in the tubular fluid, crystal adhesion to the tubular epithelium is a prerequisite for the development of intratubular nephrocalcinosis. It has been hypothesized that the tubular epithelium, in order to bind crystals, needs to be phenotypically altered. Whereas most evidence hereto is provided by in vitro experiments, we set out to illustrate this theory in vivo.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research