Incidence, predictors and associated outcomes of rhabdomyolysis after kidney transplantation | Zendy

Frank P. Hurst | Zendy; Robert Neff | Zendy; Rahul M. Jindal | Zendy; Jason A. Roberts | Zendy; Krista L. Lentine | Zendy; L Y Agodoa | Zendy; Kevin C. Abbott | Zendy

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Incidence, predictors and associated outcomes of rhabdomyolysis after kidney transplantation

Author(s) -

Frank P. Hurst,

Robert Neff,

Rahul M. Jindal,

Jason A. Roberts,

Krista L. Lentine,

L Y Agodoa,

Kevin C. Abbott

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp416

Subject(s) - medicine , rhabdomyolysis , tacrolimus , incidence (geometry) , proportional hazards model , transplantation , kidney transplantation , calcineurin , cohort , immunosuppression , statin , gastroenterology , retrospective cohort study , hazard ratio , urology , confidence interval , physics , optics

There are several case reports of rhabdomyolysis (RM) in renal transplant recipients, but the actual incidence of this complication is not known. Most of the reported cases have been attributed to drug-drug interactions with calcineurin inhibitors, with the majority of interactions reported between cyclosporine and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins). Pharmacokinetic studies have demonstrated that cyclosporine increases statin drug levels, presumably via competitive inhibition of cytochrome P450 3A4.

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