Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes | Zendy

Alessandra Perna | Zendy; Maria Grazia Luciano | Zendy; Diego Ingrosso | Zendy; Paola Pulzella | Zendy; Immacolata Sepe | Zendy; Daniel Carlos Ferreira Lanza | Zendy; Eleonora Violetti | Zendy; Rosanna Capasso | Zendy; Cinzia Lombardi | Zendy; Natale G. De Santo | Zendy

Open Access

Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes

Author(s) -

Alessandra Perna,

Maria Grazia Luciano,

Diego Ingrosso,

Paola Pulzella,

Immacolata Sepe,

Daniel Carlos Ferreira Lanza,

Eleonora Violetti,

Rosanna Capasso,

Cinzia Lombardi,

Natale G. De Santo

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp378

Subject(s) - medicine , gene , enzyme , key (lock) , metabolic pathway , biochemistry , computational biology , metabolism , biology , ecology

Hydrogen sulphide, H(2)S, is the third endogenous gas with putative cardiovascular properties, after nitric oxide and carbon monoxide. H(2)S is a vasorelaxant, while H(2)S deficiency is implicated in the pathogenesis of hypertension and atherosclerosis. Cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPS) catalyze H(2)S formation, with different relative efficiencies. Chronic kidney disease (CKD) is characterized by elevation of both plasma homocysteine and cysteine, which are substrates of these enzymes, and by a high prevalence of hypertension and cardiovascular mortality, particularly in the haemodialysis stage. It is possible that the H(2)S-generating pathways are altered as well in this patient population.

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