Low-density lipoprotein apheresis for haemodialysis patients with peripheral arterial disease reduces reactive oxygen species production via suppression of NADPH oxidase gene expression in leucocytes | Zendy

Taiga Hara | Zendy; Hideyasu Kiyomoto | Zendy; Hirofumi Hitomi | Zendy; Kumiko Moriwaki | Zendy; Genei Ihara | Zendy; Kumiko Kaifu | Zendy; Yoshiko Fujita | Zendy; Chikako Higashiyama | Zendy; Akira Nishiyama | Zendy; Masakazu Kohno | Zendy

Open Access

Low-density lipoprotein apheresis for haemodialysis patients with peripheral arterial disease reduces reactive oxygen species production via suppression of NADPH oxidase gene expression in leucocytes

Author(s) -

Taiga Hara,

Hideyasu Kiyomoto,

Hirofumi Hitomi,

Kumiko Moriwaki,

Genei Ihara,

Kumiko Kaifu,

Yoshiko Fujita,

Chikako Higashiyama,

Akira Nishiyama,

Masakazu Kohno

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp342

Subject(s) - medicine , apheresis , nadph oxidase , reactive oxygen species , hemodialysis , arterial disease , peripheral , immunology , endocrinology , vascular disease , biochemistry , platelet , biology , oxidative stress

Peripheral arterial disease (PAD) is a major complication of haemodialysis (HD), especially in patients with diabetes mellitus. Although previous reports have indicated that low-density lipoprotein apheresis (LDL-A) improves arteriosclerosis in PAD patients, the mechanism by which LDL-A affects PAD is still unclear. In this study, we tested the hypothesis that LDL-A attenuates reactive oxygen species (ROS) production in HD patients with PAD.

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