Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1 | Zendy

H. Hagele | Zendy; Ramanjaneyulu Allam | Zendy; Rahul D. Pawar | Zendy; HansJoachim Anders | Zendy

Open Access

Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1

Author(s) -

H. Hagele,

Ramanjaneyulu Allam,

Rahul D. Pawar,

HansJoachim Anders

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp339

Subject(s) - rna , interferon , rna silencing , biology , microbiology and biotechnology , chemokine , tlr3 , endocytosis , virology , receptor , rna interference , toll like receptor , gene , biochemistry , innate immune system

The molecular pathomechanisms by which viral infections trigger glomerulonephritis remain elusive. In the glomerulus, glomerular endothelial cells (GEnC) first interact with circulating viral particles; hence, we hypothesized that viral RNA, a known inducer of type I interferons and cytokines in dendritic cells, would also elicit proinflammatory antiviral reponses in GEnC.

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