Optimizing haemodiafiltration: tools, strategy and remaining questions
Author(s) -
E. Lars Penne,
Th Van Berkel,
Neelke C. van der Weerd,
Muriel P.C. Grooteman,
P. J. Blankestijn
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp333
Subject(s) - medicine , intensive care medicine
Haemodiafiltration (HDF) is considered the best dialysis therapy currently available in terms of optimal removal of both small and middle molecules. This is obtained by combining diffusive and convective clearance. The efficacy of diffusive transport is usually quantified and monitored by the assessment of small molecule clearance. For this purpose, urea clearance expressed as Kt/Vurea has been widely accepted and used as a parameter for dialysis adequacy. In contrast, it is currently unclear how the efficacy of convective transport should be quantified and monitored.
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