Open AccessEarly histological changes in the kidney of people with morbid obesity
Author(s) -
Δ. Γούμενος,
Bisher Kawar,
Meguid El Nahas,
Sara Conti,
Bart Wagner,
Charalambos Spyropoulos,
John G. Vlachojannis,
Ariela Benigni,
F. Kalfarentzos
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp329
Subject(s) - medicine , glomerular basement membrane , body mass index , proteinuria , glomerulosclerosis , biliopancreatic diversion , diabetes mellitus , urology , gastroenterology , kidney , focal segmental glomerulosclerosis , pathology , obesity , morbid obesity , endocrinology , weight loss
Morbid obesity represents a major health problem with increasing incidence worldwide. The clinical manifestation of renal involvement in obesity is proteinuria, and the histological feature is glomerulomegaly with or without focal and segmental glomerulosclerosis (FSGS). In this study, we have investigated the very early histological changes in kidneys of people with morbid obesity and no proteinuria. Patients and methods. Eighteen patients with body mass index (BMI) >50 kg/m(2) who underwent a variant of biliopancreatic diversion with Roux-en-Y reconstruction (BPD-RYGBP) and consented to undergo a renal biopsy during the surgical procedure were included in the study. The estimation of early histological changes was performed on light (n = 18) and electron microscopy (n = 13).
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