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Acetylcysteine and non-ionic isosmolar contrast-induced nephropathy--a randomized controlled study
Author(s) -
Franco Ferrario,
M. Barone,
Giovanni Landoni,
A. Genderini,
M. Heidemperger,
Matteo Trezzi,
Emanuela Piccaluga,
Paolo Danna,
D. Scorza
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp306
Subject(s) - medicine , nephropathy , creatinine , iodixanol , contrast induced nephropathy , urology , renal function , acetylcysteine , saline , gastroenterology , placebo , kidney disease , hemodialysis , surgery , anesthesia , contrast medium , endocrinology , pathology , diabetes mellitus , biochemistry , chemistry , alternative medicine , antioxidant , radiology
Intravenous administration of saline and non-ionic isosmolar contrast media significantly reduces the incidence of contrast-induced nephropathy, one of the most common causes of acute renal failure. Results with oral N-acetylcysteine are conflicting. The aim of our study was to evaluate the prophylactic role of N-acetylcysteine in patients with stable chronic renal failure undergoing coronary and/or peripheral angiography and/or angioplasty.

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