Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines | Zendy

Sven Kroening | Zendy; E Neubauer | Zendy; Jennifer Wessel | Zendy; Michael S. Wiesener | Zendy; Margarete GoppeltStruebe | Zendy

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Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines

Author(s) -

Sven Kroening,

E Neubauer,

Jennifer Wessel,

Michael S. Wiesener,

Margarete GoppeltStruebe

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp305

Subject(s) - ctgf , connective tissue , growth factor , hypoxia (environmental) , endocrinology , gene knockdown , hypoxia inducible factors , biology , medicine , downregulation and upregulation , cell culture , gene expression , kidney , cancer research , chemistry , pathology , gene , biochemistry , receptor , genetics , organic chemistry , oxygen

Hypoxia plays an important role in kidney injury. By the stabilization of the transcription factor HIF-1, hypoxia affects gene expression also in tubular epithelial cells. Increased expression of connective tissue growth factor (CTGF) is observed in different kidney diseases and is associated with deteriorating renal function. Therefore, we hypothesized that the expression of CTGF might be modulated under hypoxic conditions.

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