A cut-off value of plasma osteoprotegerin level may predict the presence of coronary artery calcifications in chronic kidney disease patients | Zendy

Marion Moréna | Zendy; AnneMarie Dupuy | Zendy; Isabelle Jaussent | Zendy; H. Vernhet | Zendy; G. Gahide | Zendy; Kada Klouche | Zendy; Anne Sophie Bargnoux | Zendy; C. Delcourt | Zendy; Bernard Canaud | Zendy; JeanPaul Cristol | Zendy

Open Access

A cut-off value of plasma osteoprotegerin level may predict the presence of coronary artery calcifications in chronic kidney disease patients

Author(s) -

Marion Moréna,

AnneMarie Dupuy,

Isabelle Jaussent,

H. Vernhet,

G. Gahide,

Kada Klouche,

Anne Sophie Bargnoux,

C. Delcourt,

Bernard Canaud,

JeanPaul Cristol

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp301

Subject(s) - osteoprotegerin , medicine , kidney disease , calcification , transdifferentiation , cardiology , coronary artery disease , vascular smooth muscle , osteopontin , vascular disease , pathology , smooth muscle , receptor , activator (genetics) , genetics , stem cell , biology

Expression of bone proteins resulting from transdifferentiation of vascular smooth muscle cells into osteoblasts suggests that vascular calcifications are a bioactive process. Osteoprotegerin (OPG) could play a key role in bone-vascular calcification imbalance and could be a marker of vascular calcification extent and progression. The purpose of this study was to evaluate relationships between vascular risk biomarkers (including classic risk factors and OPG) and coronary artery calcification (CAC) extent in chronic kidney disease (CKD) patients and to establish within the markers the appropriate cut-off value to predict CAC.

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