Simultaneous occurrence of hepatitis C virus-associated glomerulonephritis and AL amyloidosis | Zendy

Yuncan Cao | Zendy; Yuehua Zhang | Zendy; Shuang Wang | Zendy; MingHui Zhao | Zendy; Wen Zou | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Simultaneous occurrence of hepatitis C virus-associated glomerulonephritis and AL amyloidosis

Author(s) -

Yuncan Cao,

Yuehua Zhang,

Shuang Wang,

MingHui Zhao,

Wen Zou

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp296

Subject(s) - immunoelectron microscopy , medicine , amyloidosis , pathology , mesangium , glomerulonephritis , hepatitis c virus , hepatitis c , immunohistochemistry , kidney , virology , virus

We report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had a 14-year history of HCV infection with positive serum HCV RNA at presentation. Diagnosis of HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen was mainly detected as granular deposition in glomerular mesangium. AL amyloidosis was determined by electron microscopy, positive Congo red staining and identification of lambda-chain in the kidney specimen and monoclonal IgG-lambda in serum and urine. Under immunoelectron microscopy, the HCV-NS3 antigen was found in electron-dense deposits, while lambda-chains appeared in the amyloid-like filaments.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research