Open AccessAberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy
Author(s) -
Xiaojie Lin,
Jie Ding,
Li Zhu,
S. Shi,
Liping Jiang,
Mingming Zhao,
H. Zhang
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfp294
Subject(s) - medicine , nephropathy , pathogenesis , gastroenterology , immunology , diabetes mellitus , endocrinology
Immunoglobulin A nephropathy (IgAN) is associated with genetic and environmental factors, and undergalactosylation of IgA1 in the serum is considered to be a contributor to pathogenesis of IgAN. The present study was conducted to detect the galactose- (Gal) deficient IgA1 level in Chinese IgAN patients and their family members.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom