Haemodialysis-induced transient CD16+ monocytopenia and cardiovascular outcome | Zendy

K. S. Rogacev | Zendy; M. Ziegelin | Zendy; Christof Ulrich | Zendy; Sarah Seiler | Zendy; Matthias Girndt | Zendy; Danilo Fliser | Zendy; Gunnar H. Heine | Zendy

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Haemodialysis-induced transient CD16+ monocytopenia and cardiovascular outcome

Author(s) -

K. S. Rogacev,

M. Ziegelin,

Christof Ulrich,

Sarah Seiler,

Matthias Girndt,

Danilo Fliser,

Gunnar H. Heine

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp287

Subject(s) - cd16 , medicine , cd14 , leukopenia , monocyte , immunology , cardiology , flow cytometry , immune system , cd3 , cd8 , chemotherapy

Haemodialysis with bioincompatible membranes led to transient leukocyte activation and intra-dialytic leukopenia due to endothelial adherence. After the introduction of biocompatible membranes, only CD16(+) (i.e. CD14(++)CD16(+) and CD14((+))CD16(+)) monocytes showed an impressive transient intra-dialytic decrease. Presently, it is unclear whether this CD16(+) monocyte drop is detrimental. We investigated whether a prominent intra-dialytic decrease of CD16(+) monocytes predicts future cardiovascular (CV) events.

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