Alterations in proteoglycan components and histopathology of the peritoneum in uraemic and peritoneal dialysis (PD) patients | Zendy

ShinIchi Osada | Zendy; Chieko Hamada | Zendy; Takeshi Shimaoka | Zendy; Kayo Kaneko | Zendy; Satoshi Horikoshi | Zendy; Yasuhiko Tomino | Zendy

Open Access

Alterations in proteoglycan components and histopathology of the peritoneum in uraemic and peritoneal dialysis (PD) patients

Author(s) -

ShinIchi Osada,

Chieko Hamada,

Takeshi Shimaoka,

Kayo Kaneko,

Satoshi Horikoshi,

Yasuhiko Tomino

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp268

Subject(s) - versican , peritoneum , medicine , decorin , peritoneal dialysis , cd68 , pathology , peritonitis , immunohistochemistry , proteoglycan , anatomy , cartilage

Proteoglycans (PGs) are dominant extracellular matrices (ECMs) in the peritoneal tissues. Human peritoneal mesothelial cells synthesize small proteoglycans including decorin. Peritonitis and long-term peritoneal dialysis (PD) cause fibrotic changes in the peritoneum that result in ECM remodelling and PG synthesis.

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