Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor | Zendy

Maro Okamura | Zendy; Yosuke Takano | Zendy; Yukinori Saito | Zendy; Jian Yao | Zendy; Masanori Kitamura | Zendy

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Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor

Author(s) -

Maro Okamura,

Yosuke Takano,

Yukinori Saito,

Jian Yao,

Masanori Kitamura

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp243

Subject(s) - calcitriol receptor , nephrin , retinoic acid , retinoid x receptor , retinoic acid receptor , endocrinology , medicine , biology , receptor , microbiology and biotechnology , cancer research , nuclear receptor , biochemistry , gene , transcription factor , kidney , podocyte , proteinuria

Nephrin is a key molecule involved in the structure and function of the slit diaphragm in the glomerulus. We previously reported that all-trans retinoic acid (ATRA) and 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] induced expression of nephrin in murine podocytes. In this report, we investigated roles of the retinoic acid receptor (RAR), the retinoid X receptor (RXR) and the vitamin D receptor (VDR) in the regulation of the nephrin gene.

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