The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults | Zendy

Lina Artifoni | Zendy; Elisa Benetti | Zendy; Sonia Centi | Zendy; Susanegrisolo | Zendy; Gian Marco Ghiggeri | Zendy; Fabrizio Ginevri | Zendy; Luciana Ghio | Zendy; Alberto Edefonti | Zendy; C. Brambilla | Zendy; N. Cagni | Zendy; Luisa Murer | Zendy

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The impact of eNOS, MTR and MTHFR polymorphisms on renal graft survival in children and young adults

Author(s) -

Lina Artifoni,

Elisa Benetti,

Sonia Centi,

Susanegrisolo,

Gian Marco Ghiggeri,

Fabrizio Ginevri,

Luciana Ghio,

Alberto Edefonti,

C. Brambilla,

N. Cagni,

Luisa Murer

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp161

Subject(s) - methylenetetrahydrofolate reductase , enos , medicine , nitric oxide , oxidative stress , homocysteine , nitric oxide synthase , nitric oxide synthase type iii , gastroenterology , endocrinology , genotype , biology , genetics , gene

The main cause of reduced long-term graft survival is chronic allograft injury. Cardiovascular risk factors such as hyperhomocysteinaemia, accumulation of asymmetric dimethylarginine, increased oxidative stress and decreased production of nitric oxide seem to play an important role. Functional polymorphisms of the endothelial isoform of nitric oxide synthase (NOS) gene cause an alteration in nitric oxide production. Nitric oxide levels, and thus oxidative stress, are also influenced by hyperhomocysteinaemia.

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