The HSP72 stress response of monocytes from patients on haemodialysis is impaired | Zendy

Stefan Reuter | Zendy; Philip Bangen | Zendy; Bayram Edemir | Zendy; Uta Hillebrand | Zendy; Hermann Pavenstädt | Zendy; Stefan Heidenreich | Zendy; Detlef Lang | Zendy

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The HSP72 stress response of monocytes from patients on haemodialysis is impaired

Author(s) -

Stefan Reuter,

Philip Bangen,

Bayram Edemir,

Uta Hillebrand,

Hermann Pavenstädt,

Stefan Heidenreich,

Detlef Lang

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp142

Subject(s) - medicine , flow cytometry , annexin a5 , apoptosis , heat shock protein , immune system , annexin , cd14 , hsp70 , dialysis , immunology , endocrinology , andrology , biology , gene , biochemistry

Induction of heat shock proteins (HSP), i.e. of the major family member HSP70, is an important cytoprotective-resistance mechanism for monocytes/ macrophages (Mphi). Patients on haemodialysis present with a high infectious morbidity and enhanced carcinoma incidence. Renal insufficiency-related alteration of microbicidal and tumoricidal functions of Mphi, major effectors of the immune system, might promote these diseases.

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