Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function | Zendy

Pablo Javier Azurmendi | Zendy; Adriana Fraga | Zendy; Felicita Galan | Zendy; C. Kotliar | Zendy; Elvira Arrizurieta | Zendy; M. G. Valdez | Zendy; Pedro Forcada | Zendy; Joanna Stefan | Zendy; Rodolfo S. Martín | Zendy

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Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function

Author(s) -

Pablo Javier Azurmendi,

Adriana Fraga,

Felicita Galan,

C. Kotliar,

Elvira Arrizurieta,

M. G. Valdez,

Pedro Forcada,

Joanna Stefan,

Rodolfo S. Martín

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp136

Subject(s) - medicine , microalbuminuria , renal function , autosomal dominant polycystic kidney disease , creatinine , endocrinology , urology , excretion , proteinuria , urine , albuminuria , kidney disease , kidney , intima media thickness , albumin , carotid arteries

Autosomal dominant polycystic kidney disease (ADPKD) shows an increase in both urine monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (CIMT) before changes in serum creatinine concentration. Although microalbuminuria is an index of disease progression, data on whether renal alterations and vascular remodelling are already present at normal or minimally increased levels of urine albumin excretion in early stages of the disease are lacking.

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