Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study | Zendy

Benjamin D. Parker | Zendy; Joachim H. Ix | Zendy; E. C. M. Cranenburg | Zendy; Cees Vermeer | Zendy; Mary A. Whooley | Zendy; Leon J. Schurgers | Zendy

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Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study

Author(s) -

Benjamin D. Parker,

Joachim H. Ix,

E. C. M. Cranenburg,

Cees Vermeer,

Mary A. Whooley,

Leon J. Schurgers

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp024

Subject(s) - medicine , renal function , matrix gla protein , cystatin c , kidney disease , creatinine , endocrinology , gastroenterology , confidence interval , urology , hyperphosphatemia

Vascular calcification is highly prevalent in persons with chronic kidney disease (CKD) and predicts cardiovascular disease (CVD) events. Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification, and lower levels of its precursor-uncarboxylated MGP (ucMGP)--are associated with vascular calcification and atherosclerosis. Whether mild to moderate decrements in kidney function are associated with lower serum ucMGP is unknown.

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