End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells | Zendy

Thijs Hendrikx | Zendy; Evelien A. F. J. van Gurp | Zendy; Wendy M. Mol | Zendy; Wenda Schoordijk | Zendy; Varsha D. K. D. Sewgobind | Zendy; Jan N.M. IJzermans | Zendy; W. Weimar | Zendy; Carla C. Baan | Zendy

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End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells

Author(s) -

Thijs Hendrikx,

Evelien A. F. J. van Gurp,

Wendy M. Mol,

Wenda Schoordijk,

Varsha D. K. D. Sewgobind,

Jan N.M. IJzermans,

W. Weimar,

Carla C. Baan

Publication year - 2009

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfp005

Subject(s) - medicine , foxp3 , immune system , il 2 receptor , end stage renal failure , immune dysfunction , immunology , stage (stratigraphy) , t cell , hemodialysis , biology , paleontology

The defensive immune system in patients with end-stage renal failure is impaired at multiple levels. This state of immune incompetence is associated with continuous activation of the immune system. An additional explanation for this state of activation may be the disturbed function of CD4(+)CD25(bright+)FoxP3(+) regulatory T-cells.

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