Open AccessThe effect of rabbit anti-thymocyte globulin induction therapy on regulatory T cells in kidney transplant patients
Author(s) -
Varsha D. K. D. Sewgobind,
Marcia M. L. Kho,
Luc J. W. van der Laan,
Thijs Hendrikx,
TB van Dam,
Hugo W. Tilanus,
Jan N.M. IJzermans,
W. Weimar,
Carla C. Baan
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn778
Subject(s) - il 2 receptor , interleukin 7 receptor , foxp3 , medicine , immunology , ionomycin , cd8 , transplantation , peripheral blood mononuclear cell , immune system , t cell , andrology , biology , in vitro , stimulation , biochemistry
Prevention of alloreactivity by rabbit anti-thymocyte globulins (rATG) may not only result from immunodepletion but also from the induction of T cells that control allogeneic immune responses. In the present prospective and controlled study, we investigated the effect of rATG on the frequency, function and phenotype of peripheral immunoregulatory CD4+ T cells in kidney transplant (KTx) patients.
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