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Chronic peritoneal dialysis (PD) is one of the major therapies for uremic patients. However, the peritoneal mesothelial cells (PMCs) are subject to the injury by bioincompatible dialysates. The aim of this study is to investigate the protective roles and mechanisms of heat shock response in PMCs.

Heat shock response protects human peritoneal mesothelial cells from dialysate-induced oxidative stress and mitochondrial injury