Open AccessHeat shock response protects human peritoneal mesothelial cells from dialysate-induced oxidative stress and mitochondrial injury
Author(s) -
HungTien Kuo,
H.-W. Chen,
HuiHua Hsiao,
HsiangCheng Chen
Publication year - 2009
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn718
Subject(s) - oxidative stress , reactive oxygen species , viability assay , intracellular , medicine , cell damage , heat shock protein , apoptosis , pharmacology , biochemistry , chemistry , gene
Chronic peritoneal dialysis (PD) is one of the major therapies for uremic patients. However, the peritoneal mesothelial cells (PMCs) are subject to the injury by bioincompatible dialysates. The aim of this study is to investigate the protective roles and mechanisms of heat shock response in PMCs.
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