Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia | Zendy

Fabiana G. Graciolli | Zendy; Kátia R. Neves | Zendy; Luciene M. dos Reis | Zendy; Rafael G. Graciolli | Zendy; Irene L. Noronha | Zendy; Rosa Maria Affonso Moysés | Zendy; Vanda Jorgetti | Zendy

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Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia

Author(s) -

Fabiana G. Graciolli,

Kátia R. Neves,

Luciene M. dos Reis,

Rafael G. Graciolli,

Irene L. Noronha,

Rosa Maria Affonso Moysés,

Vanda Jorgetti

Publication year - 2008

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfn686

Subject(s) - endocrinology , medicine , parathyroid hormone , runx2 , kidney disease , hyperphosphatemia , osteopontin , osteoprotegerin , phosphate , calcification , parathyroidectomy , downregulation and upregulation , osteoblast , calcium , chemistry , in vitro , biochemistry , receptor , activator (genetics) , gene

Vascular calcification (VC) is commonly seen in patients with chronic kidney disease (CKD). Elevated levels of phosphate and parathormone (PTH) are considered nontraditional risk factors for VC. It has been shown that, in vitro, phosphate transforms vascular smooth muscle cells (VSMCs) into calcifying cells, evidenced by upregulated expression of runt-related transcription factor 2 (Runx2), whereas PTH is protective against VC. In addition, Runx2 has been detected in calcified arteries of CKD patients. However, the in vivo effect of phosphate and PTH on Runx2 expression remains unknown.

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