Open AccessEndogenous tissue-type plasminogen activator is protective during ascending urinary tract infection
Author(s) -
Joris J. T. H. Roelofs,
Kasper M.A. Rouschop,
Gwendoline J.D. Teske,
Gerry T. M. Wagenaar,
Nike Claessen,
Jan J. Weening,
Tom van der Poll,
Sandrine Florquin
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn562
Subject(s) - plasminogen activator , phagocytosis , escherichia coli , myeloperoxidase , microbiology and biotechnology , respiratory burst , medicine , t plasminogen activator , cytokine , tumor necrosis factor alpha , neutrophile , kidney , enterobacteriaceae , inflammation , immunology , biology , biochemistry , gene
Acute pyelonephritis is one of the most common bacterial infections. Tissue-type plasminogen activator (tPA) is a potent fibrinolytic agent, but can play a role in inflammatory processes as well.
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