Open AccessCalcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats
Author(s) -
N. Koleganova,
Grzegorz Piecha,
E. Ritz,
M.-L. Gross
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn549
Subject(s) - medicine , calcitriol , fibrosis , heart failure , kidney disease , cardiology , muscle hypertrophy , endocrinology , myocardial fibrosis , vitamin d and neurology
Remodelling of the heart, characterized by hypertrophy, fibrosis and capillary/myocyte mismatch, is observed in patients with chronic renal failure. Low vitamin D levels have been associated with increased cardiovascular risk. In the present experimental study, we studied the effects of non-hypercalcaemic doses of calcitriol on microvascular disease and interstitial fibrosis of the heart.
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